Alzheimer’s Disease is the most common cause of dementia, or memory and thinking problems that get worse over time. Some individuals maintain normal memory and thinking during life despite having significant brain pathology of Alzheimer’s Disease at autopsy after death. These individuals are considered “resilient” to Alzheimer’s Disease dementia. Microglia are the resident immune cells of the brain and are important responders to brain pathology associated with dementia. This project will use transcriptomics and spatial proteomics to identify what microglia populations exist in those “resilient” to Alzheimer’s Disease with the goal of finding ways individuals might maintain memory despite Alzheimer’s Disease pathology.
