My research investigates how microglial TBK1 signaling orchestrates immunosuppressive crosstalk among microglia, astrocytes, and T cells in breast cancer brain metastases. By defining how TBK1 shapes the metastatic brain microenvironment and enables tumor immune evasion, I aim to uncover mechanisms that can be therapeutically targeted to reprogram local immune responses. Ultimately, this work seeks to identify actionable strategies that enhance immunotherapy efficacy, disrupt metastatic progression, and improve outcomes for patients with breast cancer brain metastasis.