Enteric glia—intestine-resident glial cells—interweave with the enteric nervous system (ENS) to form an extensive cellular network spanning the entire gastrointestinal tract. However, their role in regulating non-neuronal cell function and contributing to intestinal diseases remains largely unexplored. In this project, we investigate how enteric glia orchestrate intestinal inflammation and ENS damage, providing broad insights into the emerging roles of glial-immune interactions in peripheral physiology.
